Application of 19798-77-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In the second step, the first step product 2- (1-pentyl-1H-indol-3-yl) acetic acid was added to dichloromethane (20 mL)EDCI (1.27 g) was added at room temperature,Stirring dissolved;3-Chloro-4-aminopyridine (0.9 g) was added,DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.(10 mL) was stirred for 10 min, and the organic phase was added with saturated brine (10 mL) for 10 min.The organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to give a pale yellow gum N- (3-chloropyridin-4-yl) -2- (1-pentyl-1H-indol-3-yl) acetamide (1.3 g).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-77-7, 4-Amino-3-chloropyridine.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Chen Qing; Chen Minghua; Ba Mingyu; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107151223; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem