Electric Literature of 1173081-96-3, Adding some certain compound to certain chemical reactions, such as: 1173081-96-3, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one hydrochloride,molecular formula is C8H13ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1173081-96-3.
N-((4,6-dimethyl-2-oxo-l,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H- pyran-4-yl)amino)-4-methyl-4 ‘-(morpholinomethyl)- [1,1 ‘-biphenyl] -3-carboxamide (Compound I)A mixture of 5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’- (morpho linomethyl)-[ 1,1 ‘-biphenyl] -3 -carboxylic acid (540 g, 1.23 mol) and 3-(aminomethyl)- 4,6-dimethyl-dihydro-pyridin-2(lH)-one hydrochloride (279 g, 1.48 mol) was suspended in DMSO (2.70 L) and treated with triethylamine (223 ml, 1.60 mol). The mixture was stirred at 25 C for 30 min and treated with EDC-HC1 (354 g, 1.85 mol) and HOBT hydrate (283 g, 1.85 mol). The reaction mixture was stirred at rt for 16 h. After addition of triethylamine (292 ml, 2.09 mol), the mixture was cooled to 15 C, diluted with water (10.1 L) maintaining the temperature below 30 C, and stirred at 19-25 C for 4 h. The resulting precipitate was filtered, washed twice with water (2.70 L), and dried under vacuum to give a crude product (695 g, wt-wt analysis = 78%). For the further purification of the product, recrystallization was conducted. A crude product (20.00 g, 34.92 mmol) was suspended in a mixture of ethanol (190 ml) and water (10.00 ml) and heated to 75C until a clear solution was obtained. The solution was allowed to cool to rt overnight. The precipitate was filtered, washed twice with a mixture of ethanol (30.0 ml) and water (30.0 ml), and dried under vacuum at 35 C to give the title compound as an off white solid (14.0 g, 70% recovery from the crude and 90%> yield based on wt-wt assay).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1173081-96-3, 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EPIZYME, INC.; EISAI R&D MANAGEMENT CO., LTD.; KUNTZ, Kevin W.; CHOI, Hyeong-wook; MATHIEU, Steven; SANDERS, Kristen; CHANDA, Arani; WO2015/57859; (2015); A1;,
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