Electric Literature of 7584-05-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7584-05-6, name is 3-Methylisonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 3-methylisonicotinonitrile (26, 168 mg, 1.4 mmol)in DMF (3 mL) was added 1,1-dimethoxyl-N,N-dimethylmethanamine(400 muL, 2.8 mmol). The mixture was heated to reflux overnight. Thenthe mixture was cooled to RT and additional 200 muL of 1,1-dimethoxyl-N,N-dimethylmethanamine was added to the mixture. The mixture washeated to reflux overnight. Then repeated addition of 200 muL 1,1-dimethoxyl-N,N-dimethylmethanamine to the mixture. The mixture washeated to reflux overnight. After completion of the reaction, the mixturewas cooled to RT and concentrated in vacuo to give a brown oil,the residue was purified by flash column chromatography on silica(EtOAc/Petroleum ether 1:2) to yield the yellow solid (20%). 1H NMR(400 MHz, CDCl3) delta 8.69 (s, 1H), 8.14-8.11 (m, 1H), 7.25-7.23 (m,1H), 7.16 (d, J=13.6 Hz, 1H), 5.21 (d, J=13.6 Hz, 1H), 2.95 (s, 6H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7584-05-6, 3-Methylisonicotinonitrile.
Reference:
Article; Qin, Li-Huai; Wang, Zhi-Long; Xie, Xin; Long, Ya-Qiu; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3559 – 3572;,
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