Adding a certain compound to certain chemical reactions, such as: 100367-39-3, 4-Bromo-2-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H6BrNO, blongs to pyridine-derivatives compound. COA of Formula: C6H6BrNO
EXAMPLE 22: Synthesis of N1-(7-chloroquinolin-4-vn-N2-(2-((2-methoxypyridin-4- yl)amino)ethyl)-N2-methylethane- 1 ,2-diamine. Pd(OAc)2, BINAP, K3PO4, dioxane [00257] A mixture of 4-bromo-2-methoxypyridine (0.188 g, 0.997 mmol), Nx-(2- aminoethyl)-N2-(7-chloroquinolin-4-yl)-N1-methylethane-l,2-diamine (0.278 g, 0.997 mmol), Pd(OAc)2 (24.5 mg), BINAP (0.135 g), and K3PO4 (1.14 g) in 1,4-dioxane (10 mL) was degassed with argon for 5 min and then stirred at 100 C for 20 h in a sealed tube. The reaction mixture was cooled to room temperature, filtered through Celite, and concentrated in vacuo. Purification by silica gel chromatography using CH2CI2/CH3OH/NH4OH (270:9: 1, and 180:9: 1) afforded N1-(7-chloroquinolin-4-yl)-N2-(2-((2-methoxypyridin-4- yl)amino)ethyl)-N2-methylethane-l,2-diamine (0.26 g, 67%) as a pale-yellow solid after lyophilization with CH3CN/H20. 1H NMR (300 MHz, DMSO-d6) delta 2.31 (s,3H); 2.60 (t, J = 6.3, 2H); 2.69 (t, J = 6.6, 2H); 3.12 (q, J = 5.9, 2H); 3.38 (q, J = 6.0, 2H); 3.72 (s, 3H); 5.78 (d, J = 2.1, 1H); 6.20 (dd, J = 2.0, 5.9, 1H); 6.26 (t, J = 5.0, 1H); 6.50 (d, J = 5.4, 1H); 7.14 (br t, 1H); 7.41 (dd, J = 2.1, 9.0, 1H); 7.62 (d, J = 5.7, 1H); 7.78 (d, J = 2.4, 1H); 8.17 (d, J = 9.0, 1H); 8.39 (d, J = 5.4, 1H). Mass spectrum (ESI) m/e = 386.6 (M+l).
The synthetic route of 100367-39-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRESAGE BIOSCIENCES, INC.; DECKWERTH, Thomas; KLEINMAN, Edward; RUAN, Fuqiang; BAKER, William; KLINGHOFFER, Richard; (126 pag.)WO2016/196393; (2016); A2;,
Pyridine – Wikipedia,
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