Synthetic Route of 66572-56-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66572-56-3, name is 2-Bromoisonicotinic acid, molecular formula is C6H4BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 148; (E)-2-(2-(biphenyl-4-yl)vinyl)-N-hydroxyisonicotinamide; A. (£)-2-(2-(biphenyl-4-yl)vinyl)isonicotinic acid; 7>;alpha/?5-2-(4-biphenyl)vinylboronic acid (0.224 g, 1.00 mmol) and 2- bromoisonicotinic acid (0.202 g, 1 mmol) were combined and degassed/flushed with N2. The 1,4-dioxane (4 mL) and a solution of sodium carbonate (0.286 g, 2.70 mmol) in water (1 mL) were added. The mixture was degassed/purged with N2 again. The Pd(PPh3)4 (0.058 g, 0.05 mmol) was added. The mixture was degassed/purged with N2. The reaction mixture was heated to 100 0C overnight. After cooling to RT, aq 1 N HCl was added until the pH was 4. The resultant solid was collected and washed with several portions of water and washed once with ether to yield the title compound. LC-MS: [M+l]+ 302.1 Mass: Calculated for C20Hi5NO2, 301.34
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 66572-56-3, 2-Bromoisonicotinic acid.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENENATO, Kerry, Ellen; CHOY, Allison, Laura; HALE, Michael, Robin; HILL, Pamela; MARONE, Valerie; MILLER, Matthew; WO2010/100475; (2010); A1;,
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