Adding a certain compound to certain chemical reactions, such as: 116118-98-0, 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 116118-98-0, blongs to pyridine-derivatives compound. Application In Synthesis of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid
Referenctial Example 1 5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-carboxylic acid To the solution of 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-carboxylic acid (7.6 g) in DMF (75 ml) was added di-t-butyl dicarbonate (9.6 ml), and triethylamine (5.8 ml) was titrated to the mixture. After stirring at room temperature for 3 hours and the addition of water, the reaction mixture was acidified with 1N hydrochloric acid and extracted with ethyl acetate. After the organic layer was washed with water, dried over anhydrous magnesium sulfate, the solvent was evaporated. After n-hexan and a small amount of ether were added to the residue, crystals deposited were collected by filtration to give 9.36 g of the title compound (yield, 80%). 1 H-NMR (CDCl3) delta: 1.49 (s, 9H), 2.90 (brs, 2H), 3.74 (brs, 2H), 4.51 (brs, 2H), 7.56 (s, 1H). SIMS (m/z): 284 (M+ +1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116118-98-0, its application will become more common.
Reference:
Patent; Meiji Seika Kabushiki Kaisha; US5594004; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem