Adding a certain compound to certain chemical reactions, such as: 778611-64-6, 5-Bromo-2-chloro-4-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 778611-64-6, blongs to pyridine-derivatives compound. Safety of 5-Bromo-2-chloro-4-methylpyridine
Step 1: A mixture of compound 9-1 and aqueous EtNH2 (10 mL) in NMP (5 mL) was stirred for 3 days at 80C in a sealed tube, then concentrated. The residue was diluted with EtOAc (50 mL), washed with H20 (10 mL), brine (10 mL), dried over anhydrous Na2S04, concentrated, and purified by column chromatography, eluting with PE/EA = 4/1 to give target compound 9-2 as yellow oil. LC-MS: m/z = 215.0 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,778611-64-6, its application will become more common.
Reference:
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridine – Wikipedia,
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