Adding a certain compound to certain chemical reactions, such as: 81167-60-4, 4-(tert-Butyl)-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 81167-60-4, blongs to pyridine-derivatives compound. category: pyridine-derivatives
A mixture of 2-chloro-4-terbutylpyridine (1.79 g, 10.5 mmol), 2,6-difluoro-3-pyridylboronic acid (2.6 g, 16.4 mmol), Pd(PPh3)4 (400 mg, 0.35 mmol), 2M aqueous solution of potassium carbonate (25 ml, 50 mmol) and 1,4-dioxane (80 ml) was deaerated by bubbling nitrogen through the mixture for 15 minutes. The mixture was stirred at 70C (bath) for 15 hours. The mixture was evaporated to a volume of approximately 30 ml. The residue was extracted with hexane (2 X 30 mL). The organic layers were washed with brine (20 mL) and dried over MgS04. After the evaporation of the solvent the product was purified by column chromatography (silicagel, ethyl acetate/hexane 1/2) and dried in high vacuum at room temperature. Yield 2.3 g, 88 %.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81167-60-4, its application will become more common.
Reference:
Patent; CAMBRIDGE DISPLAY TECHNOLOGY LIMITED; SUMITOMO CHEMICAL COMPANY LIMITED; STEUDEL, Annette; KOZHEVNIKOV, Valery; WO2014/9716; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem