As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5470-22-4, name is 4-Chloropicolinic acid, molecular formula is C6H4ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 4-Chloropicolinic acid
A mixture of 4-chloropicolinic acid (10.0 g, 63.4 mmol), thionyl chloride (40 ml) and a catalytic amount of DMF were heated at 80 C for 3 h. Then the reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was dissolved in 30 ml of CH2Cl2 in an ice-bath, then added to a 25% aqueous solution of ammonia (60 ml) at a rate which kept the internal temperature below 7 C with constant stirring. After 1 h, the precipitate was filtrated, washed with water (3 × 50 ml) and dried in vacuo to afford compound 2 (9.2 g, 93% yield) as a yellow solid, mp 161-162 C; 1H NMR (DMSO-d6, 400 MHz): delta 7.74-7.76 (dd, J = 1.8 and 5.3 Hz, 1H), 7.80 (br s, 1H), 8.03 (d, J = 1.8 Hz, 1H), 8.20 (br s, 1H), 8.62 (d, J = 5.3 Hz, 1H); ESI-MS m/z: 157[M+H]+; Anal. Calcd for C6H5ClN2O (%): C 46.03, H 3.22, N 17.89; Found: C 45.98, H 3.27, N 17.94.
With the rapid development of chemical substances, we look forward to future research findings about 5470-22-4.
Reference:
Article; Zhan, Wenhu; Li, Yanyang; Huang, Weiping; Zhao, Yanjin; Yao, Zhenglin; Yu, Shanyou; Yuan, Shoujun; Jiang, Falong; Yao, Shan; Li, Shuxin; Bioorganic and Medicinal Chemistry; vol. 20; 14; (2012); p. 4323 – 4329;,
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