Related Products of 154237-70-4, Adding some certain compound to certain chemical reactions, such as: 154237-70-4, name is 4-Bromo-3-cyanopyridine,molecular formula is C6H3BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154237-70-4.
Step 3, Method 15: 4-[5-(2-Fluoroethoxy)-l-benzofuran-2-yl]pyridine-3- carbonitrile[0204] To a stirred solution of [5-(2-fluoroethoxy)-l-benzofuran-2-yl]boronic acid (120 mg, 0.54 mmol) and 4-bromo-3-cyanopyridine (98 mg, 0.54 mmol) in 1,4- dioxane (3 mL) under nitrogen were added copper(I) iodide (10 mg, 0.054 mmol), caesium fluoride (163 mg, 1.07 mmol) and tetrakis(triphenylphosphine)palladium(0) (31 mg, 0.027 mmol). The reaction mixture was degassed using a stream of nitrogen for 10 minutes then heated under a nitrogen atmosphere to 60 C and stirred for 18 hours. The mixture was concentrated, ethyl acetate (10 mL) and water (10 mL) added and the layers separated. The organic layer was washed with water (2 x 10 mL), brine (2 x 10 mL), dried over magnesium sulphate, filtered and concentrated. Purification by FCC (silica, 0-30% ethyl acetate in heptane) and recrystallisation from heptane- dichloromethane (5:2) gave the title compound 46 mg (30% yield) as a yellow solid. Example 1, Method 15: 4-[5-(2-Fluoroethoxy)-l-benzofuran-2-yl]pyridine-3- carbonitrile[0205] 5H MR (500 MHz, DMSO) 9.11 (s, 1H), 8.92 (d, J= 5.4 Hz, 1H), 8.07 (d, J = 5.4 Hz, 1H), 7.93 (s, 1H), 7.64 (d, J= 9.0 Hz, 1H), 7.40 (d, J= 2.4 Hz, 1H), 7.13 (dd, J= 9.0, 2.5 Hz, 1H), 4.78 (dt, J = 47.9, 3.8 Hz, 2H), 4.30 (dt, J = 30.1, 3.7 Hz, 2H). Tr(MET-uHPLC-AB-lOl) = 3.21 min, (ES+) (M+H)+283.
According to the analysis of related databases, 154237-70-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHDI FOUNDATION, INC.; DOMINGUEZ, Celia; WITYAK, John; BARD, Jonathan; BROWN, Christopher, John; PRIME, Michael, Edward; WEDDELL, Derek, Alexander; WALTER, Daryl, Simon; GILES, Paul, Richard; WIGGINTON, Ian, James; TAYLOR, Malcolm, George; GALAN, Sebastien, Rene, Gabriel; JOHNSON, Peter, David; KRUeLLE, Thomas, Martin; MORAO, Inaki; CLARK-FREW, Daniel; SCHAERTL, Sabine; HERRMANN, Frank; GRIMM, Steffen, Kaspar; KAHMANN, Jan, Dirk; SCHEICH, Christoph; (120 pag.)WO2016/33460; (2016); A1;,
Pyridine – Wikipedia,
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