Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1480-87-1, name is 2-Fluoro-3-nitropyridine. A new synthetic method of this compound is introduced below., name: 2-Fluoro-3-nitropyridine
1.5 g of 2-fluoro-3-nitropyridine,1.5 g of tert-butyl trans-(4-aminocyclohexyl)carbamate was dissolved in acetonitrile.4 mL of triethylamine was added and reacted at 85 C for 12 hours.The reaction solution was cooled to room temperature and concentrated under reduced pressure.Adding an aqueous solution of citric acid, heating and stirring at 30 C, and vacuum filtration.The filter cake was washed with a small amount of diethyl ether to give an orange solid, which was intermediate XI.The yield was 65%.
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Reference:
Patent; Sichuan University; Yang Shengyong; Li Linli; (36 pag.)CN109180702; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem