Related Products of 131803-48-0, Adding some certain compound to certain chemical reactions, such as: 131803-48-0, name is Methyl 6-(bromomethyl)nicotinate,molecular formula is C8H8BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131803-48-0.
NaH (60%, 41.5mg, 1 .O4mmol) was added to a solution of (3) (200mg, 0.99mmol) in DMF (lOmL) at 5C under N2(g). The reaction mixture was stirred for 20 mm then methyl 4-(bromomethyl)benzoate (294mg, 1 .29mmol) was added. The stirring was continued at 70C under N2(g) for lh. The reaction was cooled to rt and poured onto water (l5OmL) and brine (5OmL), the aqueous was extracted with EtOAc (3 xlOOmL). Combined organics were dried over Na2504, filtered and concentrated invacuo. The residue was purified by flash column chromatography withCH2CI2/EtOAc (1:0-0:1) then EtOAc/MeOH (1:0-4:1) to yield (4) (251mg, 73%).1H NMR (500 MHz, Chloroform-d), OH ppm: 8.06-8.10 (m, 2H), 7.87-7.92 (m, 3H),7.78 (d, J=1.5 Hz, 1H), 7.44 (d, J=8.4 Hz, 2H), 7.23 (dd, J=8.2, 1.4 Hz, 1H), 7.15(dd, J=8.1, 4.7 Hz, 1H), 5.42 (5, 2H), 3.85 (5, 3H), 3.73 (5, 3H). LCMS (ES): Found 350.9 [M+H].
According to the analysis of related databases, 131803-48-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; TOMASSI, Cyrille Davy; CECIL, Alexander Richard Liam; MACCORMICK, Somhairle; NODES, William John; SILVA, Franck Alexandre; WO2014/181137; (2014); A1;,
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