In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6937-03-7, name is Methyl 2-aminoisonicotinate, the common compound, a new synthetic route is introduced below. Formula: C7H8N2O2
Preparation of compound 24a: imidazo[1,2-a]pyridine-7-carboxylic acid methyl esterTo a solution of 2-Bromo-1 ,1 -diethoxy-ethane (18.62 g, 0.095 mol) in H2O (80 ml) was added aq. HBr (2 ml). The resulting mixture was heated to 80 0C for 1.5 h and then was cooled to 40 0C. Then a solution of 2-Amino-isonicotinic acid methyl ester(9.61 g, 0.063 mol) and NaHCO3 (6.615 g, 0.0788 mol) in CH3OH/ H2O (3:1 400 ml) was added dropwise to the above mixture. The resulting mixture was heated to 80 0C for 18 h. The mixture was concentrated and cooled to room temperature, and the solid was collected by filtration and dried in vacuo which gave the title compound 24a as a yellow solid (9.5 g, 85.7%).
The synthetic route of 6937-03-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler; WO2010/16005; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem