Related Products of 628691-85-0, Adding some certain compound to certain chemical reactions, such as: 628691-85-0, name is 2,4-Dichloro-3-fluoropyridine,molecular formula is C5H2Cl2FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628691-85-0.
Step 2: Synthesis of 2-chloro-3-fluoro-4-(4-aminophenoxy)pyridine A solution of 4-aminophenol (24.8 g, 227 mmol) in anhydrous dimethyl sulfoxide (210 mL) was bubbled with nitrogen gas for 10 minutes, and potassium tert-butoxide (26.80 g, 238.8 mmol) was then added to get a reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes, and then 2-chloro-3-fluoro-4-chloropyridine (37.68 g, 227 mmol) was added. The reaction mixture was stirred at room temperature for 5 h, and then diluted with water (1000 mL) and extracted with ethyl acetate (500 mL*3). The organic phases were combined. The combined organic phases were washed with saline solution (500 mL*2), dried with anhydrous sodium sulfate, filtrated, and concentrated. The residue was purified by column chromatography (silica gel, petroleum ether:ethyl acetate=5:1, v/v) to get product as light yellow solid (15.0 g, yield: 28%). 1H NMR (300 MHz, DMSO-d6): delta 5.22 (br s, 2H), 6.62 (d, J=9.0 Hz, 2H), 6.75 (t, J=5.7 Hz, 1H), 6.92 (d, J=9.0 Hz, 2H), 8.05 (d, J=5.7 Hz, 1H) MS (ESI+): m/z 239.1 [M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 628691-85-0, 2,4-Dichloro-3-fluoropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PEKING UNIVERSITY FOUNDER GROUP CO., LTD.; PKUCARE PHARMACEUTICAL R&D CENTER; PKU HEALTHCARE INDUSTRY GROUP CO., LTD.; YI, Chongqin; XU, Heng; TAO, Jing; LIN, Songwen; HAN, Fangbin; (42 pag.)US2017/29404; (2017); A1;,
Pyridine – Wikipedia,
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