Adding a certain compound to certain chemical reactions, such as: 5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H8N2O3, blongs to pyridine-derivatives compound. Computed Properties of C7H8N2O3
Step 1: A solution of commercially available 6-methoxy-2-methyl-3-nitropyridine (183 mg, 1.19 mmol), [5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methanol (see preparation 1, 320 mg,1.13 mmol) and PPh3 (563 mg, 2.15 mmol) in toluene (30 ml) was cooled to 0C, DIAD (434 mg, 2.15 mmol) was added and the mixture was stirred at room temperature for 12 h. The solution was concentrated under reduced pressure to give a crude residue which was purified by flash chromagraphy to give 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((6-methyl-5-nitropyridin-2-yloxy)methyl) isoxazole (340 mg, 0.810 mmol; 68% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Phenex Pharmaceuticals AG; EP2128158; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem