In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 136818-50-3, name is 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid
To the stirred solution of lH-pyrrolo[2,3-b]pyridine-2-carboxylic acid (5, 2.5 g, 15.4 mmol) and Nu,Omicron-dimethylhydroxylamine hydrochloride (6, 1.8 g, 18.5 mmol in DCM (50 mL), was added triethylamine (10.6 mL, 77.1 mmol), HOBt (3.54 g, 23.14 mmol) followed by EDC.HC1 (4.42 g, 23.18 mmol) at 0C and the reaction mixture was stirred at room temperature for 16h. The reaction mixture was cooled to room temperature, filtered through celite and evaporated the filtrate. To the crude, added water (10 mL) and compound was extracted with DCM (30mL). Organic layer was dried over sodium sulfate and evaporated to get crude product. The crude residue was purified by gradient column chromatography using silica gel and eluent 2-4% MeOH in DCM to afford the product as off white solid. (Yield: 82%, 2.6 g). MS (ESI): mass calcd. for CioHnN302, 205.09; m/z found, 206.1 (M+H)+.
The synthetic route of 136818-50-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JUBILANT BIOSYS LIMITED; HALLUR, Gurulingappa; DURAISWAMY, Athisayamani Jeyaraj; PURRA, Buchi Reddy; RAO, N.V.S.K.; RAJAGOPAL, Sridharan; (247 pag.)WO2019/58393; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem