Reference of 15506-18-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15506-18-0, name is 1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C7H7NO3, molecular weight is 153.1354, as common compound, the synthetic route is as follows.
b) 3-({9-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)methyl]-3,9- diazaspiro[5.5]undec-3-yl}carbonyl)-1-methylpyridin-2(lH)-oneN-methyl-2-hydroxynicotinic acid (45 mg, 0.29 mmol), Intermediate A (76 mg, 0.24 mmol), HATU (91.9 mg, 0.24 mmol) and triethylamine (43 mg, 0.43 mmol) in CH2Cl2 (4 mL) were mixed and stirred for Ih. The reaction mixture was diluted with saturated aqueous sodium carbonate (2 mL) and the product was extracted with dichloromethane and dried. The pure title compound was obtained by preparative HPLC.1H NMR (399.99 MHz, CD3OD) delta 7.81-7.71 (m, IH), 7.60-7.52 (m, IH), 7.32-7.26 (m, IH), 7.23-7.16 (m, IH), 6.97-6.88 (m, IH), 6.48-6.36 (m, IH), 4.32-4.19 (m, 2H), 3.79- 3.67 (m, 2H), 3.62-3.55 (m, 3H), 3.45-3.35 (m, 2H), 3.26-3.06 (m, 4H), 2.08-1.96 (m, 2H), 1.84-1.37 (m, 14H)APCI-MS m/z: 450.5 [MH+]HPLC (Method A) Retention time: 5.63 minHPLC (Method B) Retention time: 7.07 min
The chemical industry reduces the impact on the environment during synthesis 15506-18-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; WO2007/30061; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem