Electric Literature of 55676-22-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55676-22-7, name is 3-Acetyl-6-chloropyridine, molecular formula is C7H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Tert-butyl 4-((5-acetylpyridin-2-yl)oxy)piperidine-l-carboxylate (6) Tert-butyl 4- hydroxypiperidine-1-carboxylate (5) (1.4 g, 6.94 mmol) was added to a DMF suspension (10 mL) of 60% sodium hydride (0.25 g, 6.16 mmol) at 0C . The solution was stirred at room temperature for 0.5 h. At 0C, 1-(6-chloropyridin-3-yl)ethan-1-one (4) (0.9 g, 5.78 mmol) was added and the solution was stirred for 1 h. Water was added to the reaction solution, followed by extraction with EtOAc and subsequent sequential washing with water and saline and then the resulting organic layer was dried over Na2SO4. Silica gel column chromatography provided tert-butyl 4-((5-acetylpyridin-2- yl)oxy)piperidine-1-carboxylate (6) as a white solid. MS m/z321 [M+H]+.
According to the analysis of related databases, 55676-22-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ISOCURE BIOSCIENCES INC.; ZHANG, Tinghu; CHE, Jianwei; (96 pag.)WO2018/118793; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem