Application of 128071-75-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.128071-75-0, name is 2-Bromonicotinaldehyde, molecular formula is C6H4BrNO, molecular weight is 186.01, as common compound, the synthetic route is as follows.
General procedure: A mixture of the appropriate o-haloaldehyde (1 eq, 2.60mmol), methyl propargyl ether (1.2 eq, 3.12mmol), Pd(PPh3)2Cl2 (0.04 eq, 0.10mmol), CuI (0.075 eq, 0.19mmol), Et3N (1.5 eq, 3.90mmol), in dry DMF (12mL), was stirred under nitrogen atmosphere, at room temperature for 1h. The mixture was quenched with H2O and the product was extracted with Et2O. The combined organic layers were washed with water, brine, dried over Na2SO4, and evaporated. The crude product was purified by FC (petroleum ether/AcOEt 6:4).
Statistics shows that 128071-75-0 is playing an increasingly important role. we look forward to future research findings about 2-Bromonicotinaldehyde.
Reference:
Article; Dore, Antonio; Asproni, Battistina; Scampuddu, Alessia; Pinna, Gerard Aime; Christoffersen, Claus Tornby; Langgard, Morten; Kehler, Jan; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 181 – 193;,
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