Electric Literature of 127406-56-8, Adding some certain compound to certain chemical reactions, such as: 127406-56-8, name is 4-Pyridin-2-yl-benzaldehyde,molecular formula is C12H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127406-56-8.
EXAMPLE 13; Synthesis of 3,5-dichloro-4-(pyridine-2-yl)benzaldehyde (5b)In a 40 mL tube, 4-(pyridine-2-yl)benzaldehyde (0.3 mmol, 1 equiv) and CuCl2 (8.1 mg, 0.06 mmol, 20% equiv) were dissolved in 1 mL of CI2CHCHCI2 under oxygen. The tube was sealed with a Teflon lined cap, and the reaction mixture was stirred at 1300C for 24 h. The reaction mixture was diluted with 20 mL of CH2CI2 and then treated with 10 mL of saturated Na2S aqueous solution. The mixture was filtered through a pad of Celite, and the filtrate was washed twice with brine. The organic layer was dried over Na2SO4 and concentrated under vacuum. After purification by column chromatography on silica gel with a gradient eluent of hexane and ether (Rf = 0.12 in 2:1 hexane: ether), the title product was obtained as a white solid (62.0 mg, 82%).1H NMR (400 MHz, CDCl3) delta 9.99 (s, IH), 8.78 (d, J= 4.8 Hz, IH), 7.92 (s, 2H), 7.86 (td, J= 8.0, 1.2 Hz, IH), 7.41-7.39 (m, H), 7.35 (d, J= 8.0 Hz, IH); 13C NMR (100 MHz, CDCl3) delta 189.60, 154.86, 150.23, 143.90, 137.66, 136.98, 136.34, 129.27, 124.98, 123.82; IR (thin film) v 3067, 1706, 1549, 1364, 1200 cm” ‘; HRMS (TOF) Calcd for Ci2H8Cl2NO (M + H) 258.0452, found 258.0456.
According to the analysis of related databases, 127406-56-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRANDEIS UNIVERSITY; WO2007/123910; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem