Extracurricular laboratory: Synthetic route of 6-Cyanopicolinic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,872602-74-9, 6-Cyanopicolinic acid, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.872602-74-9, name is 6-Cyanopicolinic acid, molecular formula is C7H4N2O2, molecular weight is 148.1189, as common compound, the synthetic route is as follows.name: 6-Cyanopicolinic acid

6-Cyano-pyridine-2-carboxylic acid (compound F2) (250 mg, 1.6 mmol) is dissolved in ethanol (100ml), concentrated hydrochloric acid (1 mL) and Pd/C (150 mg) are added and the mixture ishydrogenated at 3 bar hydrogen pressure for 6 h. The catalyst is filtered of and the crude product istransferred to the next step without any purification. Yield: 255 mg (85 %) mp: 214-221 C

At the same time, in my other blogs, there are other synthetic methods of this type of compound,872602-74-9, 6-Cyanopicolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; ALTANA PHARMA AG; WO2006/589; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem