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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2,3-Dichloro-5-(trifluoromethyl)pyridine

To a solution of ethyl 3- [2-hydroxy-4- (2- methoxyethoxy) phenylJbutanoate (5.50 g) in N, N- dimethylformamide (40 ml) was added sodium hydride (60% in oil, 932 mg) under ice-cooling, and the mixture was EPO subsequently stirred for 30 min. Then, 2, 3-dichloro-5- ‘ (trifluoromethyl) pyridine (3.0 ml) was added, and the mixture was stirred at room temperature for 2 hr. A saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried (MgSO4) , filtrated and concentrated. The obtained residue was subjected to silica gel column chromatography, and eluted with ethyl acetate-hexane (hexane alone to 35:65, v/v) to give ethyl 3- [2-{ [3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2- methoxyethoxy) phenylJbutanoate (7.80 g, yield: 87%) as a yellow oil.1H-NMR (300 MHz, CDCl3)S: 1.16 (3 H, t, J = 7.2 Hz), 1.22 (3 H, d, J = 7.0 Hz), 2.39 – 2.50 (1- H, m) , 2.56 – 2.70 (1 H, m) , 3.23 – 3.38 (1 H, m) , 3.43 (3 H, s) , 3.65 – 3.79 (2 H, m) , 3.96 – 4.19 (4 H, mj , 6.66 (1 H, d, J = 2.6 Hz), 6.85 (1 H, dd, J = 8.7, 2.6 Hz), 7.18 – 7.29 (1 H, m) , 7.98 (1 H, d, J = 2.1 Hz), 8.25 (1 H, d, J = 1.1 Hz).

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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem