Reference of 17228-75-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17228-75-0, name is 2,6-Dichloro-4-methoxypyridine. A new synthetic method of this compound is introduced below.
a) Synthesis of 2,6-dichloro-4-methoxy-pyridine-3-carboxylic acidTo a solution of 4.0 g (22.5 mmol) 2,6-dichloro-4-methoxy-pyridine in THF (20 ml) was added 10.0 ml (2.47 M in hexane, 24.7 mmol) n-butyllithium at -78 C. After stirring for 1 h at -78 C excess dry ice was added and the mixture was allowed to warm to RT. Then the mixture was acidified with 6N aqueos hydrochlorid acid to pH 3-4 followed by extraction with EtOAc. The organic layer was dried over Na2S04 and concentrated in vacuo. Purification of the residue by CC (hexane/EtOAc 4:1 ) provided 3.5 g (15.8 mmol, 70%) 2,6-dichloro-4-methoxy- pyridine-3-carboxylic acid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17228-75-0, its application will become more common.
Reference:
Patent; GRUeNENTHAL GMBH; KUeHNERT, Sven; BAHRENBERG, Gregor; KLESS, Achim; SCHROeDER, Wolfgang; LUCAS, Simon; WO2012/52167; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem