The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 754230-78-9, name is 3-(Benzyloxy)-5-bromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-(Benzyloxy)-5-bromopyridin-2-amine
Under argon, 200 g (0.72 mol) of 3-(benzyloxy)-5-bromopyridine-2-amine from Example 1 6A, 590 g (3.58 mol) of ethyl 2-chloroacetoacetate and 436 g of 3 Amolecular sieve were suspended in 6 1 of ethanol, and the suspension was stirred at reflux for 72 h. The reaction mixture was filtered oil through silica gel and concentrated. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=9: 1, then 6:4) and the product fractions were concentrated. This gave 221 g (79% of theory) of the target compound.10595] LC-MS (Method 16): R=1.31 mm10596] MS (ESpos): mlz=389 (M+H)j0597] ?H-NMR (400 MHz, DMSO-d5): oe=1.36 (t, 3H), 2.58 (s, 3H), 4.32-4.41 (m, 2H), 5.33 (s, 2H), 7.28-7.32 (m, 1H), 7.36-7.47 (m, 3H), 7.49-7.54 (m, 2H), 8.98 (d, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 754230-78-9.
Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; GROMOV, Alexey; FOLLMANN, Markus; BROCKSCHNIEDER, Damian; STASCH, Johannes-Peter; MARQUARDT, Tobias; TERSTEEGEN, Adrian; WUNDER, Frank; REDLICH, Gorden; LANG, Dieter; LI, Volkhart Min-Jian; (95 pag.)US2016/347770; (2016); A1;,
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