Reference of 13466-38-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13466-38-1, name is 5-Bromopyridin-2-ol. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 5-bromopyridin-2-ol (1 g, 5.75 mmol), ClCF2COONa (0.876 g, 5.75 mmol), Cs2CO3 (2.81 g, 8.62 mmol) in DMF (20 mL) was heated at 100oC for 3h. LCMS indicated that the desired compound was formed.40 mL of water and 40 mL of EA were added to the reaction mixture. The organic phase was separated, washed with water(20 mL), brine(20 mL), dried over Na2SO4, filtered and concentrated under vacuum to give a residue, which was purified by silica gel chromatography (PE/EA=100/1) to give the title compound as a colorless oil (0.3g, 23.30%).
According to the analysis of related databases, 13466-38-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EDGEWISE THERAPEUTICS, INC.; HUNT, Kevin; KOCH, Kevin; RUSSELL, Alan; SCHLACHTER, Stephen; WINSHIP, Paul; STEELE, Chris; UZOHO, Grace; (219 pag.)WO2020/97265; (2020); A1;,
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