Application of 944896-42-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 944896-42-8, name is 6-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
[Step a] To a mixed solution of compound 1 (210 mg, 533 mumol) obtained in Reference Example 65, Step b, in dioxane (4.00 mL) and water (500 muL) were added potassium carbonate (170 mg, 1.23 mmol), compound 2 (, 100 mg, 415 mumol), bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) (30 mg, 42.3 mumol), and the mixture was heated in a nitrogen atmosphere under microwave radiation at 150C, and stirred for 1 hr. The reaction solution was allowed to cool to room temperature, 1 M-hydrochloric acid (3.5 mL) was added, and the mixture was extracted with a tetrahydrofuran and ethyl acetate mixed solution (1:1). The aqueous layer was further extracted with a tetrahydrofuran and chloroform mixed solution (1:1), and the organic layers were combined, washed with saturated brine, and concentrated. The residue was subjected to solid phase extraction purification with a cation exchange resin column (Waters, PoraPak, RxnCX), and the obtained solid was suspended and washed in ethyl acetate (2.00 mL) to give compound 3 (70.0 mg, 39.4%).
According to the analysis of related databases, 944896-42-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; TAKAHASHI, Taichi; UMINO, Akinori; IIJIMA, Daisuke; TAKAMATSU, Hisayuki; (173 pag.)EP3135667; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem