Adding a certain compound to certain chemical reactions, such as: 6959-47-3, 2-(Chloromethyl)pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(Chloromethyl)pyridine hydrochloride, blongs to pyridine-derivatives compound. Quality Control of 2-(Chloromethyl)pyridine hydrochloride
A mixture of 4 (0.8 g, 5.0 mmol), sodium carbonate (2.4 g, 22.6 mmol) and 2-pyridylmethyl chloride hydrochloride (1.8 g, 10.9 mmol) in 15 mL of dry ethanol was refluxed for 12 h under N2, and then evaporated. The residue was dissolved in 50 mL of aqueous solution of sodium hydroxide and extracted with dichloromethane (3 × 30 mL). Then the organic layer was dried over potassium carbonate and evaporated. The residue was separated by silica gel flash chromatography using EtOAc as eluent to give N-(2-(bis(2-pyridylmethyl)amino)ethyl)carbamic acid tert-butyl ester 5 (1.5 g, 91%) as yellow viscous oil. 1H NMR (400 MHz, CDCl3): delta 8.52 (d, 2H, J = 4.8 Hz), 7.60 (ddd, 2H, J = 7.2 Hz), 7.39 (d, 2H, J = 7.6 Hz), 7.12 (m, 2H), 5.82 (s, 1H), 3.85 (s, 4H), 3.21(m, 2H), 2.67 (t, 2H, J = 5.6 Hz), 1.43 (s, 9H) ppm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6959-47-3, 2-(Chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.
Reference:
Article; Yan, Liwei; Ye, Zhongbin; Peng, Chunxiang; Zhang, Shihong; Tetrahedron; vol. 68; 12; (2012); p. 2725 – 2727;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem