Adding a certain compound to certain chemical reactions, such as: 1123194-98-8, 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1123194-98-8, blongs to pyridine-derivatives compound. Recommanded Product: 1123194-98-8
DMF (52mL) was added to 6-Bromo-2-methoxy-3-(4-methyl-l H- imidazol-1-yl)pyridine (13.Og, 48.5mmol) and the tert-Butyl 2- acryloylhydrazinecarboxylate (9,9g, 53.3mmol) at room temperature under nitrogen atmosphere, And the mixture was stirred at 50C for 10minutes, Tri(o-tolyl)phosphine (885mg, 2.90mmol), Palladium (II) acetate (327mg, 1.45mmol) and N,N- diisopropylethylamine (12.7mL, 72.7mmol) were added to the mixture, and the reaction mixture was stirred at 100C for 4hours. The reaction mixture was cooled to room temperature and filtrated through Celite. The residue was washed twice with DMF (6mL). Water (104mL) was added dropwise to the filtrate at room temperature over lOminutes. The mixture was stirred at room temperature for l5hoursAfter the mixture was filtrated, the residue was washed with water/DMF =2; 1(3OmL) and MTBE (3OmL). The obtained solid was suspended in MTBE (5OmL) at room temperature for 2hours, filtrated and dried under the reduced pressure to obtain the title compound (15.8g, 87% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1123194-98-8, 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; NAKAMURA, Taiju; MATSUDA, Masaaki; HU, Yongbo; HASEGAWA, Daiju; HOSHINO, Yorihisa; INANAGA, Kazato; ISOMURA, Minetaka; SATO, Nobuaki; YOSHIZAWA, Kazuhiro; MONIZ, George A.; WILKIE, Gordon D.; FANG, Francis G.; NISHIKAWA, Yoshihiro; WO2010/25197; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem