Reference of 152126-31-3, Adding some certain compound to certain chemical reactions, such as: 152126-31-3, name is 3-Fluoropicolinic acid,molecular formula is C6H4FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152126-31-3.
To 3-fluoro-2-pyridinecarboxylic acid (available from Fluorochem, 63mg, 0.44mmol) was added O-(7-azabenzotriazol-1-yl)-1 ,1 ,3,3-tetramethyluronium hexafluorophosphate (172mg, 0.45mmol), DIPEA (0.106ml) and DMF (1 ml). The reaction was stirred for 20mins at 250C. 6-(1 H-indol-4-yl)-1 H-indazol-4-amine (50mg, 0.20mmol) was added and the reaction was stirred for a further 2Oh at 250C. The solvent was dried under a stream of nitrogen to give the crude product. This sample in DMF was loaded onto an aminopropyl cartridge (5g) and after standing for 3h, the column was washed with 10% methanol in dichloromethane. The appropriate fractions were combined and dried under a stream of nitrogen to give the crude product which was purified by Mass Directed Automated Preparative HPLC (Method B). The solvent was dried under a stream of nitrogen to give the title compound (23mg). LCMS (Method B) R1 = 0.94mins, MH+ = 372
According to the analysis of related databases, 152126-31-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/147190; (2009); A1;,
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