Reference of 73290-22-9, Adding some certain compound to certain chemical reactions, such as: 73290-22-9, name is 2-Bromo-5-iodopyridine,molecular formula is C5H3BrIN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73290-22-9.
To the solution of (2-methoxyphenyl)boronic acid (0.471 g, 3.1 mmol) in 1 ,4-dioxane(20 mL), 2-bromo-5-iodopyridine (1.lg, 3.87 mmol), potassium phosphate tribasic(2.46 g, 11 .61 mmol) and water (5 mL) was added. The reaction mixture wasdegasified for 10 mm under nitrogen before the addition of Pd(PPh3)4 (0.224 g, 0.194mmol) to it. The reaction mixture was then heated at 70C for 1 h. The reactionmixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous Na2SO4. The organic layer was concentrated under vacuo to yield crude product, which was purified by column chromatography to yield title compound (0.72 g, 87.09%) as a colourless liquid.LCMS: (M+H) = 264-266; 1H NMR: (ODd3, 300MHz) 68.43-8.44 (d, 1H), 7.65-7.68 (dd, 1H), 7.42-7.45 (d, 1H), 7.29-7.34 (t, 1H), 7.19-7.23 (m, 1H), 6.99-7.01 (d, 1H), 6.92-6.96 (m, 1 H), 3.75 (5, 3H).
According to the analysis of related databases, 73290-22-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202580; (2014); A1;,
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