Synthetic Route of 144100-07-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 144100-07-2, name is 2-Bromo-6-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.
Sodium hydrogen (909.07 mg, 22.73 mmol, 60% purity) was dissolved in anhydrous THF (5 mL), the reaction was placed in an ice bath, replaced with nitrogen for 3 times, 2-bromo-6-fluoropyridine (2 g, 11.36 mmol), and 1-methylimidazolidinone (2.28 g, 22.73 mmol) were added at 0C, the mixture was stirred at 70C for 16 hours. Water (20 mL) was added to quench the reaction, then extracted with EA (3×20 mL), the organic phase was washed by saturated brine (20 mL), dried over anhydrous sodium sulfate, the filtrate was concentrated to give the crude product, the crude product was purified by column to give the 56-1. 1H NMR (400MHz, CDCl3) delta = 8.23 (d, J=8.5 Hz, 1H), 7.43 (t, J=7.7 Hz, 1H), 7.05 (d, J=7.5 Hz, 1H), 4.10 – 3.93 (m, 2H), 3.53 – 3.40 (m, 2H), 2.95 – 2.85 (m, 3H), MS m/z:256.10 [M+H]+
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 144100-07-2, 2-Bromo-6-fluoropyridine.
Reference:
Patent; Shijiazhuang Sagacity New Drug Development Co., Ltd.; QIAN, Wenyuan; YANG, Chundao; LI, Zhengwei; LI, Jie; LI, Jian; CHEN, Shuhui; (137 pag.)EP3572413; (2019); A1;,
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