Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19755-53-4, name is 2-Bromo-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Bromo-3-nitropyridine
Example 16; 1-(2-(benzo[b]thiophen-2-yl)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea; 16a. 2-(benzo[b]thiophen-2-yl)-3-nitropyridine; To a solution of 2-bromo-3-nitropyridine (75 mg, 0.371 mmol) in DME (3 mL) was added benzofuran boronic acid (132 mg, 0.802 mmol), followed by Pd(PPh3)4 (35 mg, 0.03 mmol) and K2CO3 (145 mg, 1.05 mmol). The reaction mixture was stirred at 80 C. for 16 h. The mixture was filtered and washed with CH2Cl2 (10 mL). The solvent was evaporated under reduced pressure and purified by column chromatography using 0 to 80% EtOAc in hexane over 40 min as eluting gradient to afford 16a (38 mg, 40%) as a yellowish powder. MS (ES) m/z 257 [M+H]+.
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Reference:
Patent; Bristol-Myers Squibb Company; US2006/293336; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem