Adding a certain compound to certain chemical reactions, such as: 189005-44-5, 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, blongs to pyridine-derivatives compound. Recommanded Product: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid
To a suspension of 28 g (0.10 mole) of [6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetic acid and 200 ml of methanol 6.9 ml (12.8 g, 0.13 mole) of concentrated sulfuric acid are added dropwise. The reaction mixture is heated to boiling for 3 hours, whereupon it is cooled first to room temperature and then to 5-10C under external cooling and stirred at this temperature for an hour. The precipitated crystalline product (the sulfuric acid salt of the title compound) is filtered, washed with methanol and dried. The product thus obtained is suspended in 500 ml of water and the pH is adjusted to 8 by adding a 10 % sodium carbonate solution under intensive stirring. The precipitated product is filtered, washed twice with 70 ml of water each. Thus 27.4 g of methyl-[6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetate are obtained in the form of white crystals. Yield 93.3 %, mp.: 133 -136C. IR (KBr) 2950, 1729, 1538, 1503, 1437, 1408, 1391, 1332, 1308, 1273, 1229, 1177, 1133, 1042, 994, 890, 823, 787, 753, 737, 706, 587, 553, 514, 417. 1H-NMR (CDCl3):delta, ppm 7.84 (1H, s, H-5); 7.69 (2H, d, J 8.0 Hz, H-2′,6′); 7.56 (1 H, d, J 9.2 Hz, H-8); 7.28 (2H, d, J 8.0 Hz, H-3′,5′); 7.06 (1H, dd, J 1.5 and 9.2 Hz, H-7); 4.02 (2H, s, CH2); 3.76 (3H, s, CH3); 2.40 (3H, s, CH3-4′); 2.35 (3H, s, CH3-6). 13C-NMR (CDCl3): delta, ppm 169.9 (C=O); 144.3 (C-8a); 143.9 (C-2); 137.5 (C-4′); 131.2 (C-1′); 129.2 (C-3′,5′); 128.2 (C-2′,6′); 127.5(C-7); 122.0 (C-5); 121.1 (C-6); 116.7 (C-8); 112.1 (C-3); 52.4 (COOCH 3); 30.5 (CH2); 21.2 (CH3-4′); 18.3 (CH3-6).
The synthetic route of 189005-44-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EGIS GYOGYSZERGYAR RT.; EP1259509; (2005); B1;,
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