Application of 88912-21-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 88912-21-4, name is 6-Chloro-4-methoxypicolinic acid. A new synthetic method of this compound is introduced below.
Synthesis Example 16 Synthesis of N-[(2-Trifluoromethoxyphenyl)sulfonyl]-6-chloro-4-methoxy-2-pyridinecarboxamide [Compound (I-795)] Using 2-trifluoromethoxybenzenesulfonamide [Compound (III-12)] (0.23 g, 0.96 mmol) and 6-chloro-4-methoxypicolinic acid [Compound (II-75)] (0.18 g, 0.96 mmol), the Compound (I-795) was synthesised according to the process of Synthesis Example 3. White solid, yield: 0.20 g, percent yield: 52%, m.p.: 135-138 C. IR KBr cm-1: 3372, 1728, 1598, 1440, 1356, 1262, 1192. 1H-NMR (60 MHz, CDCl3, delta): 3.80 (3H, s, OCH3), 6.9 (1H, d, J=2 Hz, pyridine ring H), 7.28-7.65 (3H, m, aromatic ring H), 7.46 (1H, d, J=2 Hz, pyridine ring H), 8.2 (1H, dd, J=2 Hz, 8 Hz, aromatic ring H), NH indistinctness.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,88912-21-4, 6-Chloro-4-methoxypicolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; Kureha Kagaku Kogyo K.K.; US6610853; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem