Related Products of 80194-70-3, Adding some certain compound to certain chemical reactions, such as: 80194-70-3, name is 3-Chloro-5-(trifluoromethyl)picolinonitrile,molecular formula is C7H2ClF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 80194-70-3.
Description 116; 3-Fluoro-5-trifluoroniethvvridine-2-carbonitrile; A suspension of cesium fluoride (9.6 g, 63 mmol) and potassium carbonate (250 mg, 1.8 mmol) in anhydrous DMSO (50 ml) under N2 was heated to 80C and Description 115 (8.7 g, 42 mmol) was added over 10 min. The reaction mixture was then heated to 95C for 20 min, cooled to 55C and poured into ice water. The mixture was extracted twice with hexane and once with DCM. The combined organic extracts were evaporated to give a solid (8 g, 100%). 1H NMR (400 MHz, CDCl3) 7.91 (1 H, d, J7.6), 8. 84 (1 H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80194-70-3, 3-Chloro-5-(trifluoromethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
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