Adding a certain compound to certain chemical reactions, such as: 717843-48-6, 3-Bromo-6-methylpicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H5BrN2, blongs to pyridine-derivatives compound. HPLC of Formula: C7H5BrN2
(3) the 2 – bromo -6 – methyl -2 – cyano pyridine (25g, 127mmol) dissolved in the 1L in concentrated hydrochloric acid (HCl), mixture in 110 C stirring reaction under the condition of 2 days; removing the solvent to obtain crude product; the obtained crude product is dissolved in water, and addingNaHCO3, then filtered; the filtrate is ethyl acetate extraction, Na2SO4drying and vacuum concentrated to get the crude product 3 – bromo -6 – methyl -2 – picolinic acid; two product adds up the yield of 69.3%, about 19g.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,717843-48-6, 3-Bromo-6-methylpicolinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Suzhou Jianxiong Vocational and Technical College; Gu, Zhun; Wang, Yang; Jin, Chen; (7 pag.)CN106045902; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem