Application of 52313-50-5, Adding some certain compound to certain chemical reactions, such as: 52313-50-5, name is Picolinimidamide,molecular formula is C6H7N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52313-50-5.
A solution of 1-(2,4-difluorophenyl)piperidin-4-one (0.24 g, 1.14 mmol) and DMFDMA (0.5 mL) in acetonitrile (5 ml) was heated with stuffing at 90 C for 2 hrs. The mixture was concentrated in vacuo and the residue was dissolved in EtOH (lOmL). To the solution was addedpyridine-2-carboxamidine (91 mg, 0.75 mmol) and potassium carbonate (210 mg, L50 mmol) successively. After being heated at 90 C overnight, the resulting mixture was cooled to rt, diluted with water (20 mL) and extracted with EA (20 mL) for three times. The organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by prep-HPLC to give 6-(2,4-difluorophenyl)-2-(2-pyridyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine (6 mg). ?H NMR (400MHz, DMSO-d6): oe 8.77 (s, 1H), 8.74 (d, 1H),8.36 (d, 1H), 7.97 (dt, 1H), 7.52 (ddd, 1H), 7.34 – 7.16 (m, 2H), 7.14 – 6.97 (m, 1H), 4.33 (s, 2H),3.48 (t, 2H), 3.10 (t, 2H). MS obsd. (ESIj [(M+H)]: 325.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52313-50-5, Picolinimidamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem