Adding a certain compound to certain chemical reactions, such as: 93683-65-9, 6-Chloro-3-nitropicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 6-Chloro-3-nitropicolinonitrile, blongs to pyridine-derivatives compound. Quality Control of 6-Chloro-3-nitropicolinonitrile
Reference Example 20 (0115) 3-Amino-6-chloropyridine-2-carbonitrile (0116) To a solution of 6-chloro-3-nitropyridine-2-carbonitrile (0.32 g and concentrated hydrochloric acid (1.2 mL) in ethanol (3.6 mL) was added iron powder (0.34 g) at room temperature, and the mixture was heated at reflux for 30 minutes. The reaction mixture was cooled to room temperature, and basified by addition of saturated aqueous sodium hydrogen carbonate solution. To the mixture was added ethyl acetate, and the resulting mixture was filtered through a Celite pad, and the filtrate was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.24 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,93683-65-9, 6-Chloro-3-nitropicolinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; Shimizu, Kazuo; Miyagi, Takashi; Ohno, Kohsuke; Ueno, Yasunori; Onda, Yusuke; Suzuki, Hikaru; (35 pag.)US2016/289206; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem