Related Products of 109-04-6 , The common heterocyclic compound, 109-04-6, name is 2-Bromopyridine, molecular formula is C5H4BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 109 B2-(tributylstannyl)pyridine; 2-bromopyridine (14.9 g, 93.1 mmol) in anhydrous THF (700 mL) was cooled to -78 C. under a stream of nitrogen gas, n-BuLi in hexane (54 mL) were added thereto and the mixture was stirred for 30 min. Tributyltin chloride (29 mL, 108 mmol) was added and the mixture was stirred, at -78 C. for 2 hours and afterwards at -20 C. for 3 hours. It was poured into an aqueous ammonium chloride solution and extracted with ethyl acetate. The organic phase was dried and the solvent was evaporated. The residue was purified by chromatography (petroleum ether/ethyl acetate=9/1) to give 2-(tributylstannyl)pyridine (12 g, yield 34%) as a yellow liquid, LC-MS (ESI) m/z: 370 (M+1)+.
The synthetic route of 109-04-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LEAD THERAPEUTICS, INC.; US2009/197863; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem