Electric Literature of 504-24-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 504-24-5 as follows.
A. 3-Iodopyridin-4ylamine. A solution of potassium iodide (19.48 g, 117.4 mmol) and iodine (18.37 g, 72.3 mmol) in water (77 ML) is added dropwise via an addition funnel to a refluxing solution of 4-aminopyridine (9.21 g, 97.8 mmol) and sodium carbonate (6.12 g, 57.7 mmol) in water (35 ML).Upon complete addition the mixture is stirred for 2 hours at reflux then cooled to room temperature and extracted with ethyl acetate.The combined organic layers are washed with saturated sodium thiosulfate solution (3*) and brine then dried over MgSO4, filtered and concentrated to give the title product (8.37 g, 38.0 mmol) and a trace of the di-iodo compound as an yellow/orange solid.This material is used in the subsequent step without further purification. 1H NMR (CDCl3, 300 MHz) delta8.70 (s, 1H), 8.10 (d, 1H), 6.55 (d, 1H), 4.60 (bs, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-24-5, its application will become more common.
Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; US2004/102450; (2004); A1;,
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