Application of 173772-63-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.173772-63-9, name is 3-Amino-2,4-dichloropyridine, molecular formula is C5H4Cl2N2, molecular weight is 163.01, as common compound, the synthetic route is as follows.
3-Amino-2-4-dichloropyridine d (0.7047g, 4.32mmol), phenylboronic acid (0.5177g, 4.24mmol), K2CO3 (0.8023g, 5.80mmol), and Pd(PPh3)4 (0.0702g, 0.0607mmol) were combined. The sample was evacuated and purged with nitrogen three times. Dry DMF (2mL) and deoxygenated H2O (0.4mL) were added. The sample was microwaved at 13O0C for 40 minutes. The reaction mixture was diluted with H2O (50 mL) and extracted with EtOAc (3 X 50 mL). The EtOAc extracts was dried over MgSO4 and filtered. The crude material was adsorbed onto silica gel and purified by flash chromatography (4Og SiO2, 0-30%EtOAc in hexanes) to give 3-amino-4-chloro-2- phenylpyridine e (0.435g, 2.12mmol, 49%).
Statistics shows that 173772-63-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-2,4-dichloropyridine.
Reference:
Patent; GENENTECH, INC.; WO2007/106192; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem