In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7379-35-3, name is 4-Chloropyridine hydrochloride, the common compound, a new synthetic route is introduced below. Formula: C5H5Cl2N
Amine F-11: 2-(1-(Pyridin-4-yl)piperidin-4-yl)ethanamine dihydrochioride(i): Tert-butyl 2-(piperidin-4-yl)ethylcarbamate (0.2 g, 0.876 mmol), 4-chloro-pyridinium chloride (0.197 g, 1.314 mmol) and N-ethyl-diisopropylamine (0.37 ml, 2.19 mmol) were refluxed for 15 hours in 2-propanol (10 ml). Saturated sodium hydrogen carbonate solution (20 ml) and ethyl acetate (50 ml) were added, the phases were separated, and the aqueous phase was extracted with ethyl acetate (2.x.50 ml). The combined organic phases were dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by column chromatography (silica gel, ethyl acetate/dichloromethane/methanol/ammonia (25percent aq.), 400:100:50:1). Yield: 80 mg (30percent).
The synthetic route of 7379-35-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GRUENENTHAL GmbH; US2010/173889; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem