Synthetic Route of 143468-13-7, Adding some certain compound to certain chemical reactions, such as: 143468-13-7, name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine,molecular formula is C7H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 143468-13-7.
General procedure: The appropriate heterocycle (1 equiv.) was dissolved in a mixture of DMF and THF (1:1 or 1:1.5 respectively, 0.2 M). The solution was cooled to 0 C and sodium hydride (1.2 or 2.2 equiv.) carefully added portion wise. After approximately 5 min the alkyl halide (1.2 equiv.) was carefully added portion-wise. The reaction mixture was stirred at 0 C or at RT for 15 min. to an hour then heated at 80 C for a period ranging between 30 min to 6 h. The reaction mixture was cooled to 0 C and quenched with water and treated with EtOAc and the organic layer separated. The organic solvent was dried (using either MgSO4, Na2SO4 or a phase separator) and subsequently removed under vacuum. The residue was purified by flash silica column chromatography or reverse phase column chromatography to give the product.
According to the analysis of related databases, 143468-13-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB Biopharma SPRL; The designation of the inventor has not yet been filed; (80 pag.)EP3527209; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem