Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H7BrN2
[0196] A stirred mixture of 5-bromo-6-methylpyridin-3-amine (0.100 g, 0.535 mmol), 4,4,5,5,4?,4?,5?,5?-octamethyl-[2,2?jbi[[1 ,3,2] dioxaborolanyll (0.136 g, 0.535 mmol), [1,1 bis(diphenylphosphino)ferrocenej dichloropalladium(II) complexed with dichloromethane (1:1) (42 mg, 0.051 mmol) and potassium acetate (0.150 g, 1.53 mmol) in 1,4-dioxane (5.0 mL) was heated at 110C. After 2 hours, the reaction was quenched with saturated aqueous NH4C1, and extracted with DCM (3 x30 mL). The organic layers were combined, dried over Na2SO4, and concentrated. The crude product was used directly in the next step without further purification.
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Reference:
Patent; INCYTE CORPORATION; LU, Liang; WU, Liangxing; SHEN, Bo; YAO, Wenqing; (114 pag.)WO2016/134294; (2016); A1;,
Pyridine – Wikipedia,
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