Related Products of 152684-30-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.152684-30-5, name is 5-Bromo-2-methoxy-3-nitropyridine, molecular formula is C6H5BrN2O3, molecular weight is 233.02, as common compound, the synthetic route is as follows.
a) 5-(1 -Benzyl-1 H-pyrazol-4-yl)-2-methoxy-3-nitropyridineAn oven-dried resealable Schlenk tube was charged with 5-bromo-2-methoxy-3- nitropyridine (3.58 g, 15.36 mmol), 1 -benzyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan- 2-yl)-1 H-pyrazole (5.23 g, 18.43 mmol), potassium carbonate (4.24 g, 30.72 mmol), 1 ,4-dioxane (50 mL) and water (5 mL). The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon, and tetrakis(triphenylphosphine)palladium(0) (1 .77 g, 1 .53 mmol) was added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was sealed and the mixture was stirred and heated in an oil bath to 100 C. After 3 days, the mixture was cooled, filtered through diatomaceous earth (Celite) and the filter cake was washed with methylene chloride (300 mL). The combined filtrate and washings were concentrated in vacuo and the residue was purified by flash chromatography (20-50% ethyl acetate in hexanes) to give the title compound (3.70 g, 84%) as a yellow solid.1H-NMR delta (CDCIs): 4.1 1 (s, 3H), 5.36 (s, 2H), 7.33 (m, 5H), 7.64 (d, 1 H), 7.81(d, 1 H), 8.30 (d, 1 H), 8.49 (d, 1 H).
Statistics shows that 152684-30-5 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-methoxy-3-nitropyridine.
Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; BACH TANA, Jordi; PAGES SANTACANA, Lluis Miquel; WO2013/17461; (2013); A1;,
Pyridine – Wikipedia,
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