Electric Literature of 145100-50-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide. A new synthetic method of this compound is introduced below.
Intermediate 11 (0.15 g, 0.76 mmol) was dissolved in 2.5 mL anhydrousdichloromethane under N2. 0.21 mL (1.22 mmol) of N,NDiisopropylethylaminewas added and stirred for 15 min at roomtemperature. The reaction was cooled to 0 C and 0.33 g (0.91 mmol) 2-pyridyltriflimide was added and the reaction stirred overnight at roomtemperature. At completion extraction was done with dichloromethane(3 × 10 mL) and the organic fractions washed with saturated aqueoussodium chloride before being dried over sodium sulfate and concentratedin vacuo. Purification was done by flash chromatography 95:5(DCM:MeOH) to yield 0.06 g (25%) of the product as a light red oil. TLCeluents used (9:1 Dichloromethane: MeOH). 1H NMR (500 MHz;CDCl3): delta 7.18 (t, J = 7.9 Hz, 1H), 7.12 (d, J = 7.5 Hz, 1H), 7.07 (d,J = 8.0 Hz, 1H), 3.10-3.01 (m, 2H), 2.84 (dd, J = 16.0, 10.6 Hz, 1H),2.77-2.71 (m, 2H), 2.44 (s, 6H), 2.23-2.18 (m, 1H), 1.67-1.62 (m, 1H).13C NMR (400 MHz, CDCl3): delta 148.23, 139.75, 129.72, 129.54, 127.07,123.54, 120.35, 118.54, 117.17, 113.97, 59.95, 41.94, 32.51, 25.20,23.62. Calcd C13H17NO3SF3 for [M + H]+: 324.0881. Found:324.0083.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, and friends who are interested can also refer to it.
Reference:
Article; Perry, Charles K.; Casey, Austen B.; Felsing, Daniel E.; Vemula, Rajender; Zaka, Mehreen; Herrington, Noah B.; Cui, Meng; Kellogg, Glen E.; Canal, Clinton E.; Booth, Raymond G.; Bioorganic and Medicinal Chemistry; vol. 28; 3; (2020);,
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