Synthetic Route of 16063-69-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16063-69-7, name is 2,4,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.
Based on the coupling described by Tan et al.63 trans-2-Phenylvinylboronic acid (2.546 g, 17.2 mmol), K3P04 (7.307 g, 34.4 mmol), and PdC12(PPh3)2 (0.362 g, 0.52 mmol) were dissolved in 100 mL THF. To this mixture, 2,4,6-trichloropyrimidine (3.156 g, 17.2 mmol) dissolved in 20 mL THF was added producing a cloudy yellow suspension. H20 (15 mL) were added, and the now clear solution was heated at reflux for 7 h. Approximately 100 mL of H20 were added, and the biphasic mixture was extracted three times with ether. The combined organic layers were washed with brine, dried over anhydrous MgSO4, and the solvent removed with a rotary evaporator. The product purified by column chromatography (5-10% EtOAc in hexanes) to provide 1 (3.161 g, 73%). ?H NMR (500 MHz, CDC13) oe 6.95 (d, J=15.87 Hz, 1 H), 7.22 (s, 1 H), 7.41 (m, 3 H), 7.59 (dd, J=7.45, 2.08 Hz, 2 H), 7.96 (d, J=15.87 Hz, 1 H). ?3C NMR (500 MHz, CDC13) oe 117.1, 123.0, 128.2,129.2, 130.6, 134.8, 140.9, 160.7, 162.8, 166.6. HRMS (ESIj m/z calcd for C,2H9N2Cl2251.0143, found 251.0101. mp 119-121 C (recryst. from EtOAc/hex)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16063-69-7, 2,4,6-Trichloropyridine.
Reference:
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; DUCKE UNIVERSITY; KATZENELLENBOGEN, John; MCDONNELL, Donald; NORRIS, John, D.; PARENT, Alexander; POLLOCK, Julie; GUNTHER, Jillian; CARLSON, Kathryn, E.; MARTIN, Teresa; WO2015/48246; (2015); A1;,
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