08/9/2021 News Share a compound : 83004-10-8

Electric Literature of 83004-10-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83004-10-8, name is 2-Bromo-6-(bromomethyl)pyridine, molecular formula is C6H5Br2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 0.050 g (0.169 mmol) of 3-(3,4-dimethyl-benzoyl)-6-fluoro-lH- quinolin-4-one 4tt in 1.0 mL of tetrahydrofuran was added 0.4 mL (0.5 M in toluene, .203 mmol) of potassium hexamethyldisilazide and the reaction solution was stirred for 5 min, followed by the addition of 50.9 mg (0.203 mmol) of 2-bromo-6-bromomethyl-pyridine in 0.5 ml of tetrahydrofuran. The resultant solution was stirred at 60 C for 3 h. The reaction solution was quenched by the addition of water and the aqueous phase was extracted with 3 x 5 mL of ether. The combined organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to yield 58 mg of l-(6-Bromo-pyridin-2-ylmethyl)-3-(3,4- dimethyl-benzoyl)-6-fluoro-lH-quinolin-4-one 4tt as a yellow solid: LC-MSD, m/z for C24Hi8BrFN2O2, [M+H] = 465.4, 466.5, 467.4, 468.4; Reverse phase HPLC gradient, 20-95% acetonitrile with 0.1% TFA in 4 minutes, retention time = 2.8 min;1H NMR (400 MHz, CDCl3): delta 8.27 (IH, s), 8.12 (IH, m), 7.64 (IH, s), 7.56 (IH, m), 7.51 (IH, m), 7.47 (IH, m), 7.40-7.34 (2H, m), 7.19 (IH, m), 7.00 (IH, m), 5.46 (2H, s), 2.32 (3H, s), 2.31 (3H, s).

According to the analysis of related databases, 83004-10-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2007/59108; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem