Synthetic Route of 63071-09-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63071-09-0, name is 2-Hydroxymethyl-3-methylpyridine, molecular formula is C7H9NO, molecular weight is 123.15, as common compound, the synthetic route is as follows.
A portion (605.3 mg) of the obtained product was dissolved in chloroform (30 ml) and then added with manganese dioxide (3.03 g) (chemicals treated, manufactured by Wako Pure Chemical Industries, Ltd.), followed by stirring at 70C for 2 hours. After completion of reaction, the catalyst was removed by filtration with Celite and the solvent was concetrated. The residue was purified by silica gel column chromatography (chloroform/ethyl acetate=1:1), to thereby obtain a light orange liquid of the subject compound (419.8 mg). MS (FAB,Pos.) :m/z= 122 [M+1]+1H-NMR(500MHz,CDCl3) : delta=2.67(3H,s),7.40(1H,dd,J=7.8,4.6Hz),7.64(1H,d,J=7.8Hz) ,8.67(1H,d,J=4.6Hz) ,10.2(1H,s) .
Statistics shows that 63071-09-0 is playing an increasingly important role. we look forward to future research findings about 2-Hydroxymethyl-3-methylpyridine.
Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1431290; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem