Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1034467-80-5, name is 5-Cyclopropyl-2-fluoropyridine. A new synthetic method of this compound is introduced below., category: pyridine-derivatives
A mixture of 5-cyclopropyl-2-fluoropyridine (543 mg, 2.92 mmol), (R)-tert-butyl 3- aminopyrrolidine-l-carboxylate (400 mg, 2.92 mmol) and Cs2C03 (1904 mg, 5.84 mmol) in DMSO (2 mL) was stirred at 160 C for 24 hours. The mixture was cooled to RT diluted with water (20 mL) and extracted with EtOAc (20 mL*3). The combined organic phase was concentrated and the residue was purified by flash chromatography on silica gel (PE/EtOAc = 2/1) to afford (R)-tert- butyl 3-((5-cyclopropylpyridin-2-yl)amino)pyrrolidine-l-carboxylate (35 mg, 4%) as a yellow solid. [M+H] Calc?d for CI7H25N302, 304.1; Found, 304.1.
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Reference:
Patent; KINNATE BIOPHARMA INC.; KANOUNI, Toufike; ARNOLD, Lee D.; KALDOR, Stephen W.; MURPHY, Eric A.; TYHONAS, John; (0 pag.)WO2020/6497; (2020); A1;,
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